Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Loyal employees of this auto services company are rewarded on their 10th anniversary -- and every five years after --with a weekend getaway at a resort in Boca Raton, Fla. (The company is headquartered just 15 minutes away.)
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Self-driving cars, selfie sticks, drones, touchscreen devices, e-cigarettes, jetpacks, and many other things seem like fairly modern inventions. Indeed, most of their "inventors" list them as newly invented and even go as far as seeking patents. But the fact is, many of these "inventions" have already been in existence for quite some time. They may have earlier lookalikes that ended up not going into production or that went into limited production due to one reason or another. Some also made it into full production but were recalled due to poor sales.
An otherworldly romance between a mysterious aquatic creature and a mute girl, played by Sally Hawkins.
While Insead’s joint programme dropped back into second place, its single-school programme moved up three places to fourth, a place it last occupied in 2011.
Trends and targets in antiviral phototherapy
Makers of processed food, soda and fast food see markets in the developing world as their greatest growth opportunities. At the same time, obesity rates and weight-related illnesses are on the rise in developing countries. An ongoing series of articles examined the interaction of these two trends, starting with cases in Brazil, Ghana and Colombia. Taken together, these stories reveal “a new global food order, and a new health crisis.”
他会在自己的独唱专辑中尝试什么样的歌曲呢：《Sweet Creature》（《可爱的人儿》）和《Ever Since New York》（《自从来到纽约》）是温馨的原声抒情歌曲；而在《Kiwi》（《奇异果》）这首歌中，他大声地炫耀着自己的欢乐；《Two Ghosts》（《两只幽灵》）则是一首为分手而惋惜的歌曲。
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
One side of the capsized Eastern Star was rolled above water at 7:30 am Friday, as rescuers worked through the night to right the upturned ship in the Yangtze River. The side that has emerged shows "Eastern Star" in Chinese character on the hull.
Novel biosensing methodologies for ultrasensitive detection of viruses
Polls indicate that the Dutch election will be extremely tight. Mr Rutte’s centre-right VVD sits atop most polls, just 3 percentage points ahead of the PVV. Most polls show a large percentage of voters remain undecided.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
May the New Year be a time of laughter and real enjoyment for you. Best wishes.
活跃的ETF市场将取决于基于收费的分销网络的发展。富达国际(Fidelity International)亚太区董事总经理陶博宏(Mark Talbot)表示，分销基础设施正抑制零售需求。
ACE2 as a potential therapeutic target for pandemic COVID-19
Kate Winslet is another Brit who’s opted for the loo for her best actress Academy Award, which she was awarded for her complex role as a concentration camp guard in the 2008 adaptation of Bernhard Schlink’s novel, The Reader.
Diagnostic technologies for COVID-19: a review
2014年，演员蒂尔达·斯文顿(Tilda Swinton)在四部电影中戴着假牙：《零点定理》(The Zero Theorem)、《布达佩斯大饭店》、《唯爱永生》(Only Lovers Left Alive)，以及奉俊昊导演的《雪国列车》(Snowpiercer)。在最后这部惊悚片中，斯文顿饰演残酷、狡猾的梅森部长(Minister Mason)，她戴着一副大大的眼镜，有一口庞大、丑陋的牙齿。
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
宾夕法尼亚州立大学的气候科学家迈克尔·E·曼恩(Michael E. Mann)在电子邮件中说，“如果不是由于燃烧化石燃料所产生的、导致地球变暖的气体排放越来越多的原因，在上千年史无前例的几十年较暖期间、创纪录地变暖的十年中，看到变暖的又一个记录年度，是非常不可能的。”
New Year's greetings and best wishes!
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Speculative trading of agricultural commodities has been a feature of the markets’ volatility in 2016, and Rabobank expects the trend to continue.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
值得注意的是，本年度传播假消息之首的网站域名当属“abcnews.com.co.” 在十一月的一次Verge的采访中，伊利诺伊州大学信息科学学院的Nicole A. Cooke教授引用了一个假新闻网站上的消息，这个假新闻网站使用的是危险和普遍的策略，即域名和真网站看上去只有微小的区别。他们让消息源从第一眼看上去具备真实性。管理abcnews.com.co的人告诉华盛顿邮报，他相信他的网站在特朗普大选期间充当了一个重要的因素。
Antiviral drug discovery: broad-spectrum drugs from nature
Influenza neuraminidase: A druggable target for natural products
They're developing a core and sorting through roles. Because they're the Lakers, there remains the possibility that a solid free agent or two will look their way.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The role of biosensors in the detection of emerging infectious diseases
不过，在长达四小时的马拉松般的颁奖典礼中，《月光男孩》所获奖项一度与《爱乐之城》并驾齐驱。巴里?詹金斯（Barry Jenkins，文首图中）和塔雷尔?阿尔文?麦克拉尼（Tarell Alvin McCraney，文首图右）获得了最佳改编剧本奖。马赫沙拉?阿里(Mahershala Ali)获得最佳男配角奖，这是美国穆斯林男演员首位获得奥斯卡奖。
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
This is all bad news for investors, just as America's 30-year bond bull is ending.
The emotions were far more visceral and less attractive.
1. glitterati / n . 知名人 士，国际上层社会人士。
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
“I don’t think there are any companies that have survived big assaults from two of the biggest beasts in the hedge fund jungle,” says Ms Simpson of Calpers. “He is cool, calm and collected — the corporate exemplar of ‘Keep calm and carry on’.”
China's newly issued lunar New Year monkey stamps marking 2016, another Year of the Monkey, also designed by Huang and each with a face value of 1.20 yuan, have attracted much attention, with collectors lining up outside post offices ahead of their release.
Inhibition of SARS coronavirus helicase by bismuth complexes
Hillary stays on: Clinton’s CV is chock full of firsts: The only first lady to become a U.S. senator turned viable presidential candidate turned secretary of state. Now a private citizen, she continues to be one of the most watched and listened-to women on the planet. All bets on that she will be the 2016 Democratic presidential candidate and the free world’s presumptive next leader. She’s done little to quiet the chatter, including hitting the speaking circuit last month at an estimated $200,000 fee per event and inking a reported $14 million book deal.
小说作者安东尼·赫洛维兹（Anthony Horowitz）透露，新书《Trigger Mortis》为现代读者作了改动，包含反对吸烟的信息，而且首次有一位“直言不讳”的同性恋朋友出场。
All held together with imported white stilton cheese, the flakes are interspersed on the pie with dollops of Ossetra caviar from the Caspian Sea as well as truffles and Fois Gras from France.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Two colors! It may not sound revolutionary, but everything is relative. And know this: It’s not about indecision, but social progress. That’s Pantone’s position, anyway.
We also do not want any trade war with others and we have stuck to reform of the yuan's exchange rate formation mechanism to keep it basically stable at reasonable and equilibrium levels.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Cliff Stevenson, an anti-dumping expert who publishes the report based on data filed with the WTO, said the surge in US cases was driven largely by the steel industry. The increase also represented the range of countries from China to Australia, the UK and the Netherlands against which US companies were willing to file anti-dumping complaints.
DNA from the bones matched that of descendants of the king's sister, while the skeleton had the twisted spine and battle injuries consistent with contemporary accounts, said researchers from the University of Leicester.
Company: Project Frog
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Mayweather Jnr - who is capable of demanding pound 70 million a fight - fell to 16th. He pocketed pound 20 million in ring fees with an additional pound 5 million coming mostly from his clothing brand TMT, The Money Team.
but that was markedly lower than the previous month’s rise of 8.2 per cent.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
China does not want to see a trade war between the US and China. That would not make our trade fairer and cause loss for the both sides.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Bill Gates topped the list of the world's richest billionaires for the 17th time in 22 years, it has been revealed.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
14. Google Calendar
It is not hard to think of recent examples, from Hugo Chávez to Viktor Orban and Vladimir Putin.
A teenage student in Southwest China's Chongqing Municipality has been sentenced to one year in jail after trying to poison fellow students for being too noisy in class, local media reported last Wednesday.
朱克斯提醒，我们目前正处于第四次超级大泡沫之中，它是美联储在保守经济学兴起以来的30年时间里吹起来的。他将这个泡沫称为“暂时没有名字的泡沫”(Bubble With No Name Yet)。好，大家来给这个新泡沫命名吧。但不管你叫它什么，都要快点起名，因为它马上就要爆了，就像过去30年相继破灭的亚洲泡沫、互联网泡沫和信贷泡沫一样。
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
“Yao represents the new wave of wealth creation by financial investments in China,” said Rupert Hoogewerf, who compiles the annual list.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
The No. 1 thing in job security is your relationship with your boss. Even if he says, "I'm sorry I really wanted to keep you, but they made me lay you off," that's almost never true. He probably made that decision.
Lecent was with an unknown number of other youth when she was killed by a single bullet inside a home in a public-housing complex near Martin Grove Rd. and Finch Ave W.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
People (read: your boss) will notice if you go from sporting a uniform of jeans and a T-shirt to showing up in a tailored suit on interview day. This is all the more reason to take the day off from work to interview, but if you don't, dress as usual at the office. And then, Foss says, "leave the premises, and stop in a McDonald's parking lot on the way to the interview to change."
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Captivating, funny and possessed of a surprise-filled zig-zag structure that makes it impossible to anticipate where it's headed, this is a deeply humane film that, like the best Hollywood classics, feels both entirely of its moment and timeless.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
That price looks excellent given that Tucker should fit more neatly in a three-and-d role than Ross, Sullinger is a total non-factor, and the Raptors kept their own 2017 first-round pick.
This is a thorny issue that’s unique to messaging apps. We expect ads to live alongside content we consume. We don’t expect them to crop up in our one-on-one communications. “The last thing you want in a personal conversation is a banner ad or pop-up that interrupts that,” Wray says. “It might work with more impersonal networks, but specifically within messaging, people hate traditional ads.”
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
o Battery power may turn out to be a transition technology. Cost reductions have been slow in coming, and Tesla needs a 30% improvement in order to build the $35,000 Model 3 it has promised for 2017. Toyota’s recent move was eye-opening. It is allowing a battery-supply deal with Tesla to expire and instead will redouble its work on hydrogen fuel cells. The cost of fuel cells is coming down faster than batteries and fuel cell proponents believe drivers will prefer a relatively rapid refuel with hydrogen to waiting hours to recharge their batteries.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
My Dear Wife
Barney Thompson is legal correspondent
A modular microarray imaging system for highly specific COVID-19 antibody testing
New year’s events can be anticlimactic. Not so in China where stock markets began 2016 with enough excitement to make traders choke on their bubbles: Shanghai stocks dropped 7 per cent on Monday, Shenzhen more than 8 per cent. It could have been worse. A new mechanism that suspends trading after a drop of 7 per cent halted play early — in this instance, by an hour and a half.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
"Why do the slaves all dress in white and look like fairies in this drama? Plus they even ran faster than horses. Is it reasonable?" user Shiweitian said.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Hartz started Eventbrite, an online ticketing platform, with her now-husband Kevin in 2006. Since its founding, the company has raised $140 million from firms like Sequoia Capital and Tiger Global Management and reached $2 billion in gross ticket sales this September. Entrepreneurship forced Hartz to appreciate candid and collaborative conversations. "I had to learn how to ask for help," she says. "Everyone always thinks it's brave to go out alone, but I think it's even braver to put yourself out there in front of others, and to figure out how to work together."
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Columbia Pictures克里斯蒂安?贝尔、艾米?亚当斯和布莱德利?库珀在电影《美国骗局》中早在1月份闹片荒的时候，人们不会想到今年会迎来如此多好电影。不仅如此，有几部影片甚至达到了被我们在心目中理想化了的那些老电影的水准。今年有两部电影脱颍而出。纯娱乐片方面，赢家显然是《美国骗局》(American Hustle)，这部由大卫?欧?拉塞尔(David O. Russell)执导的影片讲述了上个世纪七十年代的行骗高手和他们的微妙骗术的故事，幽默诙谐，令人捧腹。而从创新角度看，《地心引力》(Gravity)的全新拍摄技术给观众带来了新的观影体验。人们普遍认为《美国骗局》无可挑剔，这部疯狂喜剧片是一部时代佳作。我个人则认为，《地心引力》是今年的最佳影片。
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
1. How to make pancakes
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
A facile assay for rapid detection of COVID-19 antibodies
n. [计]定序；排序；订购 v. 命令；指挥；订购（o
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
The Republican candidate appeared unsure at times and occasionally stumbled over his lines as if struggling to remember his briefing notes. He began sweating as Obama, aggressive from the start, got the better of him during exchanges on Iran, Iraq and Russia as well as on US military spending.
当芬兰程序员Jerry Jalava 2008年遇到车祸，他面临双重悲剧。首先，他失去了他的手指，对于靠打字生存的人来说是个大问题。其次，他必须跟一个幽默感过剩的医疗小组打交道。了解了他的遭遇后，一位外科医生竟然提议Jalava应该出门去买个“USB手指驱动器”。
The collaboration with business is important, adds Teach First, not just for the funding but to help schools equip students with more of the skills required by modern employers.
While D'Aloisio spends 80 percent of his work time retooling and improving Summly (which has already been integrated into Yahoo!'s iPhone app), the other 20 percent is devoted to imagining the expansive challenges he'll take on next. He predicts there will be summarization programs that do for video what Summly does for the written word. He has grand thoughts about using technology to aid learning and would like to help fellow autodidacts while disrupting the old educational models.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
这部由塞巴斯蒂安.马拉比(Sebastian Mallaby)所著的《知者：格林斯潘传》(The Man Who Knew)，是这项奖金额为3万英镑的奖项的第12位获奖者。该奖项奖励的是年度“最令人瞩目和愉悦的”图书。
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
The third gunman, Amedy Coulibaly, who stormed a kosher supermarket on Friday,never left for such training, said Valls.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Rounding out our top five is Sandra Bullock, one of only two women on our list (the other is Jennifer Lawrence in 10th place). Bullock had two big hits this year in two very different genres: Gravity was a tense thriller that will likely earn her another Oscar nomination, while The Heat was a cop comedy that kicked butt at the box office, bringing in $230 million globally.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
'My first duty, my first responsibility was to be true to the original feel of the book, to be true to Ian Fleming: his creation, his world and his ideas.
Anti-HIV drug repurposing against SARS-CoV-2
We will deepen rural reform.
Length-scale dependence of protein hydration-shell density
最佳迷你剧集/电影类编剧：D?V?蒂文森斯(D.V. DeVincentis)，《美国罪案故事：公诉辛普森》，“玛西亚，玛西亚，玛西亚” (The People v. O. J. Simpson: American Crime Story, "Marcia, Marcia, Marcia")
More than 430,000 students from 1,767 universities in 31 provinces, municipalities and autonomous regions across China were surveyed. Of the respondents, 89.2% had considered starting a business, with 18.2% reporting firm intentions to do so.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Trailing China in 2015 was the UK with $1.9 billion, Japan, $1.8 billion, India, $1.6 billion, and South Korea, $1.5 billion.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
According to exam questions and some test-takers' feedback posted online after the exam, the difficulty of the questions was moderate and hot political and social issues, such as the Long March rockets, China's foreign affairs, the Yutu lunar rover and entrepreneurial efforts by college students, were mentioned.
About this collection
2015年FT/麦肯锡最佳商业图书奖(2015 Financial Times and McKinsey Business Book of the Year)的获奖作品是《机器人的崛起：大规模失业的威胁与科技》(The Rise of the Robots: Technology and the Threat of Mass Unemployment)，这本书对工作自动化的未来做出了令人不安和常常令人消沉的分析。
10. The difference between a lie and a promise is that the believer of a lie is the listener and the believer of a promise is the speaker.