Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Mrs. May’s government proposed a rule that would publicly shame employers who hired foreign workers. And her first major speech was full of barbs directed against multiculturalism, including a jab against people who claimed to be “citizens of the world,” whom she called “citizens of nowhere.”
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Elspeth Cheung, head of BrandZ valuation at Millward Brown, says: “The top 10 used to be dominated by consumer goods. This year, it’s technology.”
Trends and targets in antiviral phototherapy
“Policymakers around the world are cognisant of the impact the Fed decision will have and are worried, which makes us worried,” said Simon Lue-Fong, head of global emerging debt at Pictet Asset Management. “People are saying the decision is priced in but seeing as no one knows exactly what will happen how can that possibly be true.”
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
After Zhou contaminated the water, one of Zhou's classmates surnamed Tang noticed that the water coming out of the dispenser was milky and had a pungent scent.
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
ACE2 as a potential therapeutic target for pandemic COVID-19
Diagnostic technologies for COVID-19: a review
High and rising US rates may quickly become drivers of EM crises: such conditions may lead to higher borrowing costs in EMs, along with capital outflows and an unwillingness by the financial sector to take risks.
Amazon founder Jeff Bezos rose to No. 3 on the list for the first time, thanks to the jump in in Amazon shares, which boosted his net worth to $72.8 billion.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Having reached the current stage of development, China can now advance only through reform and innovation. We have the largest quality workforce as well as the largest pool of scientists, engineers and professionals in the world, and their potential for innovation is truly tremendous.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Lawrence Yun, the trade group's chief economist, expects the average 30-year fixed-rate mortgage to hit 5.5% at year-end, up from 4.5% late last year and 3.5% in the first half of 2013. That's a sharp runup in a short period of time, one that could harm affordability and spook even more buyers.
“He’s had more of a sense of swagger and confidence” in recent months, says Jan Dawson of Jackdaw Research.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Much joy to you in the up coming year. May the warmest wishes, happy thoughts and friendly greetings come at New Year and stay with you all the year through.
Antiviral drug discovery: broad-spectrum drugs from nature
Though Hand was British Petroleum's SVP of Global Brand, Marketing and Innovation, for several years, she's on a much more environmentally friendly mission today. Project Frog aims to revamp the construction industry with simple-to-build spaces (they takes days, rather than months to construct) that consume about 50% less energy than traditional buildings for sectors like education and healthcare. Hand's plan seems to be working: revenue is expected to more than double this year.
当晚的最大赢家可能还要属主持人蒂娜?费和埃米?珀勒，这是两人第二次搭档主持金球奖颁奖典礼，且她们今年表现丝毫不逊去年，创下了1,970万观众的六年来最高收视率。金球奖颁奖典礼由好莱坞外国记者协会(Hollywood Foreign Press Association)举办，举办地点位于加利福尼亚州贝弗利山庄的贝弗利山希尔顿酒店(Beverly Hills Hilton)。
Influenza neuraminidase: A druggable target for natural products
His parents only realised what was going on when the bank called them to let them know about the charges.
TAXES: Approximately $16,866 in 2014
The city offers excitement beyond your expectations, with grand churches, a richly varied number of museums, a growing modern-art scene and streets that come alive with summer festivals.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
HEC Paris and London Business School have tightened their grip on the top of the Financial Times rankings of pre-experience and post-experience Masters in Finance programmes respectively, having dominated the finance rankings since they were first published in 2011.
The role of biosensors in the detection of emerging infectious diseases
On Turkey, which recently shot down a Russian warplane, Putin said he sees no possibility of overcoming the strained ties with the current Turkish leadership. He said he was shocked to see that Turkey hadn't tried to explain its action but turned to help from NATO instead.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
4. Adidas. Brand love: 35% / Rank 25
Taylor Swift has been named the most charitable celebrity of 2012.
A record 27,817 civil service jobs are being offered this year by central government departments and subsidiaries.
Mr Lam predicts that any recovery in the market will rely on appetite from cash-rich companies from mainland China, with foreign investors restricting their investments to real estate investment trusts or stocks exposed to developers, rather than actual property.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
All kinds of companies say they plan to add senior systems analysts, whose base pay is projected to rise 5% over this year's levels, to as high as $85,500; financial analysts, whose salaries will start at $81,500 at large companies, 4.8% more than in 2010; and experienced administrative assistants, at starting salaries of up to $41,750, a 3.1% increase.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
The Meyerowitz Stories
Inhibition of SARS coronavirus helicase by bismuth complexes
Indeed, everyone from Jennifer Garner, to January Jones and Kylie Jenner have been photographed as they pick out their most spook-worthy pumpkins in time to send October out with a thrill.
6. “Taxi”(Jafar Panahi)
It was last above 50 - the threshold separating contraction from expansion - in February.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
A report from the ministry showed that employers recruited 5.2 million workers through public employment service agencies in the first quarter, dropping 229,000, or 4.5 percent, from the previous year.
Whatever the underlying cause, last year’s extreme warmth in the West meant that Alaska, Arizona, California and Nevada all set temperature records. Some parts of California essentially had no winter last year, with temperatures sometimes running 10 to 15 degrees above normal for the season. The temperature in Anchorage, Alaska’s largest city, never fell below zero in 2014, the first time that has happened in 101 years of record-keeping for the city.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
I wish you a happy New Year. All affection and best wish
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
China's consumer price index (CPI), a main gauge of inflation, rose by 1.6% in 2017, lower than the yearly control target of 3%, the National Bureau of Statistics (NBS) said on its website.
GM is addicted to hefty sales incentives to move the cars and new CEO Ed Whitacre knows it. In 2010, he will slash incentives and end up abandoning GM's 20% U.S. market share target to find profitability. The search will prove elusive.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
One of the more notorious incidents was when Zhu Ling, a student at the prestigious Tsinghua University, was paralyzed when her roommate allegedly poisoned her with thallium in 1994.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Piano and ballet performance “On My Fingertips And Toes” (Lang Lang and Hou Honglan)
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
According to local media, the gang, based in Nanning, the capital city of south China's Guangxi Zhuang autonomous region, was able to make up to 16,000 yuan (￡1,750) profit on every tonne of the putrid meat, by injecting it with chemicals, increasing its weight by 50 per cent.
What? Hasn't his firm made enough money off Bernanke's cheap money printing? So he's blaming 'lower growth on fiscal austerity, ' even as Bernanke keeps blowing up the Fed's balance-sheet bubble by trillions under the delusion he's America's savior because our dysfunctional Congress failed?
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
The Cnzz.com report also discusses the problem of the 'free-to-play' business model that's prevalent in China's online game sector. While many games companies in the U.S., for example, charge subscription fees, most Chinese games utilize the free-to-play model, which allows players to try out a game without paying. The longer players stay in the game, the more likely they will be to pay for in-game items to move up into higher levels of play. But that also means that people who spend the most money are the best performers.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
节目13 歌曲《嫦娥》，李玉刚 景海鹏 刘旺 刘洋
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
3. Not starting your own business
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
WhatsApp had been particularly ad-averse before its sale to Facebook. CEO Jan Koum kept a note from co-founder Brian Acton taped to his desk to remind him of the company’s core values. It read: “No Ads! No Games! No Gimmicks!”
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
“My manifesto with Summly was to get our technology into as many users’ hands as possible,” Mr D’Aloisio said, pointing to Yahoo’s hundreds of millions of users. “With Yahoo’s reputation as a content portal, we have an opportunity to fundamentally change the way content is consumed.”
Germanyjust hung four onPortugal. It was a bit of a shocking result, at least from the perspective that most observers expectedPortugalto put up a bit more fight. But it was another relatively high-scoring game at World Cup 2014? Not surprising at all.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Despite the breakthrough, Jack Ma, chairman of Alibaba Group, said there was no need for human beings to fear machines.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
A modular microarray imaging system for highly specific COVID-19 antibody testing
Apple CEO Tim Cook
'In total I've spent about ￡5,000 in three months on my three girls. One dress cost me $200 and she only wore it twice before she grew out if it - but I don't intend to lower my spending.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
明星们的私家飞机刚停稳，“老爹身材”一词便在互联网上走红。男性微胖的身材成为潮流，荧幕上不少这样的例子。法新社（AFP）Deborah Cole（黛博拉?科尔）写道：“杰拉尔?德帕迪约（Gerard Depardieu）在《爱之谷》中的形象便是“大汗淋漓、气喘吁吁地打着赤膊”， 华金?菲尼克斯 （Joaquin Phoenix）在 伍迪?艾伦（Woody Allen）的新片《非理性的人》（Irrational Man）中也露出了他那胖胖的肚子。科林?法瑞尔（Colin Farrell）出席《龙虾》（The Lobster）的首映红毯时，看起来如往常一般衣冠楚楚，然而在剧中他却大腹便便。为了给荒诞主义者欧格斯?兰斯莫斯（Yorgos Lanthimos）的黑色喜剧中的孤独主角增肥，法瑞尔大量进食高热量食品，其中包括融化了的冰淇淋。他告诉《好莱坞报道》（Hollywood Reporter），“在早晨10点享用2个芝士汉堡、薯条和可乐可不那么有趣，”他补充道，“不过我喜欢芝士汉堡。”
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
“We have resolved this matter and will move forward to build on the important actions Honda has already taken to address our past shortcomings in early warning reporting,” said RickSchostek, Honda executive vice president, in a statement. “We continue to fully cooperate with NHTSA to achieve greater transparency and to further enhance our reporting practices.”
Enthusiastic supporters of the idea of a “universal basic income” for all citizens, meanwhile, will look to Finland where a trial is now well under way. In France, Emmanuel Macron will try to tread a delicate line in 2018 as he reforms the labour market, hoping to inject flexibility without increasing insecurity or incensing the unions.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
保障房倡导者们则担心，如果重新区划做得不认真，那么居民社区或将迅速士绅化。“看看威廉斯堡(Williamsburg)发生了什么吧，”城市正义中心(Urban Justice Center)的社区开发项目负责人哈维·艾普斯坦(Harvey Epstein)说，他指的是房价上涨，“我不明白，它怎么就不可能发生在东纽约、布朗克斯或者法拉盛呢。”
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Video footage recorded by the RSPCA shows the house littered with mess, including animal faeces.
According to Feng Zhenglin, head of the Civil Aviation Administration of China, weather accounted for 56.8% of flight delays in 2016, up from 29.5% the previous year.
A facile assay for rapid detection of COVID-19 antibodies
Rossello also has pledged to work closely with a federal control board that U.S. Congress created last year to oversee Puerto Rico’s finances, and he has said he supports negotiations with creditors to help restructure a nearly $70 billion public debt.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
May the New Year be a time of laughter and real enjoyment for you. Best wishes.愿新年不仅是你欢笑的时刻，更是你欣喜的日子。祝福你。
Klay Thompson added 19 points and Andrew Bogut scored 13 for the Warriors, off to the best start by an NBA team since Dallas won its first 14 games in 2002-03. Golden State needs three wins to equal the league record of 15-0, held by the 1948-49 Washington Capitols and 1993-94 Houston Rockets.
Along with having her artwork featured on Google's homepage, Zhang wins a $30,000 college scholarship. In addition, her school will receive a $50,000 Google for Education technology grant, and the company is donating $20,000 in her name to a charity dedicated to bringing clean water to schools in Bangladesh.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Take targeted and powerful measures to strengthen areas of weakness.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Please accept my season\'s greetings.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
This founding father argued that the college would both guard against the desire in foreign powers to gain an improper ascendant in our councils and ensure the office of President will never fall to the lot of any man who is not in an eminent degree endowed with the requisite qualifications.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
It adds up to a pointed reminder that Her Royal Swiftness can reclaim her place at pop's cutting edge whenever she feels like it.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
vt. 编预算，为 ... 做预算
Anti-HIV drug repurposing against SARS-CoV-2
Also important to EMBA entrepreneurs was the support of their school and alumni network. About three-quarters of entrepreneurs thought that both the school and their alumni network were helpful or very helpful when setting up their company. “Alumni support was key to getting the idea vetted and getting the right contacts needed for the business”, said one.
"When the actual dependency ratio of pension insurance gets down to three to one, the payment cannot be lower than 17 percent. If it drops to two to one ratio, it means that everyone is going to pay 25 percent. The financial burden gets heavier when the dependency ratio gets lower. The restructuring of pension system must be finalized in two years." Yang said.
Length-scale dependence of protein hydration-shell density
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
“One person had his wife call to tell his boss he was not coming back.”
*最佳真人秀主持：鲁保罗?查尔斯(RuPaul Charles)，《鲁保罗变装皇后秀》(RuPaul’s Drag Race, Logo)
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
“Insead enormously boosted our intercultural experience,” said one alumni survey respondent from Switzerland. “It is a place to learn global culture better than anywhere else.”
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9. Putting Yourself in Someone Else's Shoes Improves Memory